Biochem/physiol Actions

Cell permeable: no

Reversible: yes

Product does not compete with ATP.

Primary Targettrypsin- and cysteine-like proteases

General description

A reversible inhibitor of trypsin-like proteases and cysteine proteases. Also known to inhibit activation-induced programmed cell death and to restore defective immune response in HIV⁺ donors. Often used for the inhibition of endoproteinase Lys-C, kallikrein, papain, plasmin, thrombin, cathepsin B, and trypsin. Leupeptin does not inhibit chymotrypsin, elastase, renin, or pepsin. The recommended working range is 10-100 µM for most applications.

A reversible inhibitor of trypsin-like proteases and cysteine proteases. Also known to inhibit activation-induced programmed cell death and to restore defective immune responses of HIV⁺ donors. Also available as a 50 mM solution in H₂O (Cat. No. 509281).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Montenez, J.P., et al. 1994. Toxicol. Lett. 73, 201.Sarin, A., et al. 1994. J. Immunol.153, 862.

Packaging

5, 10, 25 mg in Plastic ampoule

50 mg in Glass bottle

100 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Aqueous stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.

Sequence

Ac-Leu-Leu-arginal, hemisulfate

Warning

Toxicity: Standard Handling (A)